Bacteria innovation delivers hope for cancer patients: A groundbreaking project has shown how bacteria spores could be the ideal means of delivering targeted medicines to tumours.
Spores of Clostridium engineered for clinical efficacy and safety cause regression and cure of tumors in vivo
Efficient Secretion of Murine IL-2 From an Attenuated Strain of Clostridium sporogenes, a Novel Delivery Vehicle for Cancer Immunotherapy
Colonisation of Clostridium in the body is restricted to hypoxic and necrotic areas of tumours
Advancing Clostridia to Clinical Trial: Past Lessons and Recent Progress
Use of an optimised enzyme/prodrug combination for Clostridia directed enzyme prodrug therapy induces a significant growth delay in necrotic tumours
E. coli nitroreductase NfsA is a reporter gene for non-invasive PET imaging in cancer gene therapy applications
Repeated cycles of Clostridium-directed enzyme prodrug therapy result in sustained antitumour effects in vivo
Clostridium to treat cancer: dream or reality?
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